Insecticide For Scabies

Scabies is a skin inflammation caused when microscopic insects called mites burrow into the skin. Scabies are spread easily through direct skin to skin contact, and can live anywhere on the body of adult human beings. Using insecticides to kill scabies is an effective home care treatment as well as being a permanent cure for the disease. Scabies is a disease caused by the Sarcoptes scabiei mite. It is spread through physical close contact with an affected person. Symptoms include severe itching, sometimes accompanied with a rash. There is no known curative treatment of scabies except man-made insecticides like permethrin. These insecticides must be applied on skin. Mites can be killed if a liberal amount of these insecticides are applied to areas where the mites have burrowed in, i.e., the hands and wrists, elbows, armpits, waistline, inner thighs and buttocks.

Insecticide For Scabies

 Permethrin is the active component of topical creams widely used to treat human scabies. Recent evidence has demonstrated that scabies mites are becoming increasingly tolerant to topical permethrin and oral ivermectin. An effective approach to manage pesticide resistance is the addition of synergists to counteract metabolic resistance. Synergists are also useful for laboratory investigation of resistance mechanisms through their ability to inhibit specific metabolic pathways.

Methodology/principal findings: To determine the role of metabolic degradation as a mechanism for acaricide resistance in scabies mites, PBO (piperonyl butoxide), DEF (S,S,S-tributyl phosphorotrithioate) and DEM (diethyl maleate) were first tested for synergistic activity with permethrin in a bioassay of mite killing. Then, to investigate the relative role of specific metabolic pathways inhibited by these synergists, enzyme assays were developed to measure esterase, glutathione S-transferase (GST) and cytochrome P450 monooxygenase (cytochrome P450) activity in mite extracts. A statistically significant difference in median survival time of permethrin-resistant Sarcoptes scabiei variety canis was noted when any of the three synergists were used in combination with permethrin compared to median survival time of mites exposed to permethrin alone (p<0.0001). Incubation of mite homogenates with DEF showed inhibition of esterase activity (37%); inhibition of GST activity (73%) with DEM and inhibition of cytochrome P450 monooxygenase activity (81%) with PBO. A 7-fold increase in esterase activity, a 4-fold increase in GST activity and a 2-fold increase in cytochrome P450 monooxygenase activity were observed in resistant mites compared to sensitive mites.

Conclusions: These findings indicate the potential utility of synergists in reversing resistance to pyrethroid-based acaricides and suggest a significant role of metabolic mechanisms in mediating pyrethroid resistance in scabies mites.

Insecticide For Scabies

Scabies is a common skin condition that’s caused by a parasite. The parasite burrows under the skin, causing itchy red bumps and blisters. It can also cause other symptoms like:

-A rash with tiny pimples or red spots that may itch

-Skin around the fingers, wrists, elbows, armpits and groin area

-Sores that don’t heal for weeks or months

-A general feeling of illness for several days before symptoms appear

List Of Insecticide For Scabies