Fleas are small insects that live on the bodies of animals and have been known to cause infections in humans as well. They tend to be spread by contact with an infected pet or their environment. For example, if you live in an apartment complex where your neighbors have dogs, they may bring home fleas from their yard or dog park and drop them off on your porch or belongings when they visit.
Simparica Trio is a new treatment for fleas. It is a preventative for dogs and cats, including dogs with flea allergy dermatitis. It comes in three different doses—one for spot-on application (for dogs), one for spot-on application (for cats), and one for oral administration (for both dogs and cats).
The active ingredient in Simparica Trio is milbemycin oxime, which is a very effective flea treatment. It kills the flea by disrupting its nervous system, making it unable to bite. It also kills adult fleas on contact and prevents them from reaching maturity by interfering with their development.
Simparica Trio is a topical treatment for flea infestation and it is available in three different strengths: 1/2 fl oz, 3/4 fl oz, and one-eighth fl oz. The active ingredient in Simparica Trio is nitenpyram, which is an insect growth regulator. The product also contains 2% SLS (sodium lauryl sulfate), which helps break down the fleas’ protective coating.
The active ingredient in this product is nitenpyram, which is an insect growth regulator. Nitenpyram can kill adult fleas within 24 hours of application. It also controls flea eggs and larvae by killing them before they hatch.
Simparica Trio works by breaking down the outer layers of the flea’s body so it dies from dehydration or starvation. This happens because the product contains both an insect growth regulator and a surfactant that causes the outer layer of the flea’s body to dehydrate and die from lack of water or nutrition.
Does Simparica Trio Kill Fleas?
Simparica Trio is a flea control treatment that is made by Bayer. It contains three different active ingredients, which are bifenthrin, permethrin and lambda cyhalothrin. These ingredients are all chemical insecticides that have been used extensively in the past to kill fleas. They work by killing fleas through contact with their skin, which means they can cause serious harm to pets if ingested by your pet or children. Because of this risk, you should never use Simparica Trio on any animal that has been shown to be allergic to one of these chemicals.
The question of whether Simparica Trio Kills Fleas is one that can be answered in a number of ways. First, there are several different types of fleas that can be found on dogs and cats. Some of these fleas are more common than others, but all of them can cause an array of health problems for your animal. To find out which ones you’re dealing with, take a look at our infographic below:
Second, there are many different types of flea treatments available to pet owners today. If you have pets at home or work with animals that need care, you may not be able to handle everything by yourself. For example, if you have dogs or cats who are allergic to flea bites and certain types of medication, it’s important to find something that works quickly and effectively without causing any harm.
How Does Simparica Trio Kill Fleas?
Simparica Trio is a chewable tablet that kills fleas. It contains the active ingredient milbemycin, which prevents flea eggs from hatching and larvae from developing into adults. The tablet also contains imidacloprid, which is an insect growth regulator (IGR). IGRs are toxic to fleas, causing them to die within four hours of ingestion.
Simparica Trio’s active ingredient, milbemycin, functions by acting on a specific receptor on the flea’s body. This receptor gives instructions to the flea’s nervous system, telling it when and where to lay eggs. Milbemycin blocks this receptor, preventing the communication between the flea and its nervous system. The result: no eggs are laid or larvae develop into adults.
Can a Dog Still Get Fleas While on Simparica?
The answer is yes, your dog can still get fleas while on Simparica. While the medication works to kill the adult fleas and eggs, it does not treat or prevent eggs from hatching. Because of this, you should continue to take care of your pet’s environment to prevent any potential new infestation.
For example, if your dog has been living in an untreated yard during their illness and recovery period, you may want to treat their home with Simparica to help prevent reinfestation. If they were previously treated with a different product that they have not yet finished using before starting on Simparica, it will likely work as well.
How Long Does It Take Simparica Trio to Kill All Fleas?
The length of time it takes for Simparica Trio to kill all fleas depends on how many fleas you have and what type of flea treatment you’re using.
If your pet has a large population of fleas, you’ll need to treat them for at least four weeks. If the infestation is very heavy, it may take longer than four weeks. In this case, you’ll want to contact your vet to see if they recommend another form of treatment that could be more effective than Simparica Trio.
How Toxic Is Simparica Trio to Humans and Pets
The active ingredient in Simparica Trio is dinotefuran. Dinotefuran is a chemical that is toxic to humans and pets, but it’s not immediately fatal. The Centers for Disease Control and Prevention (CDC) and the Environmental Protection Agency (EPA) say that people should not handle dinotefuran-treated dogs, cats, or rabbits. The EPA also recommends not letting children under 5 years old play with the treated dogs or cats.
Inhalation of the chemical can cause burning in the throat, nose, and lungs. Symptoms of inhalation may include coughing and wheezing; cough may produce blood-tinged secretions from the airway passages and sinuses. Exposure to high levels of airborne dinotefuran may result in respiratory irritation and inflammation of the airways as well as pulmonary edema, which can be fatal if left untreated.
Exposure to high levels of dinotefuran may result in skin irritation at low concentrations and eye irritation at higher concentrations. Short-term exposure can cause nausea and vomiting, while long-term exposure may cause gastrointestinal symptoms such as abdominal pain or diarrhea.
List of Flea Repellent and Where to Buy
A flea repellent is a product that is applied to the skin or clothes and helps prevent fleas from biting. There are a variety of different types of flea repellents, including sprays, shampoos and lotions. They can be purchased at most stores or online.

Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 3 Doses)
Price : $33.14
Features :
- Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 5-22 lbs.
- Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
- Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
- Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
- Lasting flea and tick protection: Frontline’s long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.
Additional Info :
Color | orange |
Item Dimensions | |
Height | 4.5 Inches |
Width | 0.75 Inches |
Length | 5.75 Inches |
Weight | 0.8 Pounds |

Vet’s Best Flea and Tick Home Spray | Flea Treatment for Dogs and Home | Plant-Based Formula | 32 Ounces
Price : $9.97
Features :
- GENTLE PROTECTION: Vet’s Best Flea & Tick Home Spray uses certified natural ingredients to kill fleas, flea eggs, and ticks on contact.
- PROVEN EFFECTIVE: Whether facing an active infestation or are applying for routine prevention, our spray is scientifically proven effective against pests but gentle enough to use around the whole family.
- CERTIFIED NATURAL OILS: Each steam-distilled essential oil is selected for its potent pest-fighting properties and is 100% Certified Natural.
- TOTAL HOME DEFENSE: Applies easily on surfaces, indoors and out, including dog bedding, crates, furniture, blankets, upholstery, carpets, outdoor surfaces, and more. Also gentle enough to be applied directly on dogs and puppies 12 weeks or older.
- MADE IN THE USA: Our products are proudly manufactured in the USA with quality domestic and internationally sourced ingredients.
Additional Info :
Color | Green |
Item Dimensions | |
Height | 0.81 Inches |
Width | 3.38 Inches |
Length | 3.38 Inches |
Weight | 2 Pounds |

Frontline Plus Flea and Tick Treatment for Dogs (Medium Dog, 23-44 Pounds, 3 Doses)
Price : $33.14
Features :
- Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use on dogs 23-44 lbs.
- Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
- Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
- Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for dogs and puppies 8 weeks and older
- Lasting flea and tick protection: Frontline’s long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for dogs works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.
Additional Info :
Color | Blacks & Grays |
Item Dimensions | |
Height | 4.5 Inches |
Width | 0.75 Inches |
Length | 5.75 Inches |
Weight | 0.0625 Pounds |

FRONTLINE Plus for Cats and Kittens (1.5 pounds and over) Flea and Tick Treatment, 3 Doses
Price : $33.14
Features :
- Waterproof flea and tick treatment for cats and kittens: Frontline Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your cat. This product is approved for use on cats and kittens 1.5 lbs and over.
- Break the flea life cycle with frontline: Frontline flea and tick treatment for cats kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
- Kills fleas and ticks: Frontline flea and tick treatment for cats kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease.
- Trusted flea and tick protection for cats: Frontline Plus for Cats has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult fleas and ticks and the second to kill flea eggs and larvae – this fast-acting, long-lasting protection provides flea and tick control for cats and kittens 8 weeks and older.
- Lasting flea and tick protection: Frontline’s long-lasting formula is stored in the oil glands of the cat’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick treatment for cats works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.
Additional Info :
Color | Green |
Item Dimensions | |
Height | 0.5 Inches |
Width | 4.5 Inches |
Length | 6 Inches |
Weight | 0.07054792384 Pounds |

CAPSTAR (nitenpyram) Oral Flea Treatment for Dogs, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Medium & Large Dogs (Over 25 lbs), 6 Doses
Price : $36.99
Features :
- FAST-ACTING FLEA TREATMENT: One oral flea tablet starts killing fleas within 30 minutes.
- TACKLE FLEA INFESTATIONS FAST: Give Capstar oral flea treatment and watch dead fleas fall off your pet.
- TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas, simply give another dose as often as once a day.
- WITHOUT A VET PRESCRIPTION: Flea treatment without needing a veterinarian prescription, administer this cat flea tablet orally to kill adult fleas fast.
- KILL ADULT FLEAS: Capstar oral flea treatment tablets (57 mg) are safe for dogs and puppies from 25.1-125 lbs., four (4) weeks and older.
Additional Info :
Color | Green |
Item Dimensions | |
Height | 4.5 Inches |
Width | 5.75 Inches |
Length | 0.63 Inches |
In Conclusion
Simparica Trio is a fantastic flea treatment for cats and dogs. It works by targeting the three stages of the flea life cycle: egg, larvae, and adult. This means that your pet will be protected from all three stages of the flea’s life cycle at once, so they won’t have to deal with any pesky fleas in between treatments. Simparica Trio is made up of three different ingredients that work together to kill adult fleas on contact. Each ingredient has its own specific function, which makes it easier than ever to understand how Simparica Trio works.
You’ll find that Simparica Trio gives you a more thorough treatment than other flea treatments on the market today. That’s because it targets all three stages of the flea life cycle in one shot, rather than using just one or two ingredients as most other brands do.
Simparica Trio also comes with a range of benefits that make it worth buying over other brands. The first benefit is that it can effectively treat both pets and their owners at once. You don’t have to worry about what happens if your pet has been bitten by an infected flea before you start treatment – Simparica.